Rebecca Caine was born in Toronto and studied at the Guildhall School of Music, London.
Uniquely, her career has been divided between Opera and Musical Theatre, making her West End debut at 19 in the role of Laurey in Oklahoma! She then sang the role of Eliza in My Fair Lady on the National tour. While making her debut at Glyndebourne as Amor in L'incoronazione di Poppea, she was asked to join the Royal Shakespeare Company where she created the role of Cosette in Les Miserables. After a successful West End run she joined the original cast of Phantom of the Opera to play Christine opposite Michael Crawford. She then returned to Toronto to repeat the role in the Canadian premiere of Phantom of the Opera. During her run in Toronto she joined the Canadian Opera Company to make her highly praised North American debut in the title role of Lulu.